Adrenal Dysfunction from Thyroid Hormones

Since it is a necessity for good health, vitality, and overall body function, the adrenal gland secretes hormones such as estrogen, testosterone, and cortisol. These glands eventually become the major sources of endogenous sex hormones in both men and women after mid-life. Modern lifestyles filled with prolonged physical and emotional stress or chronic illness can eventually lead to fatigue of the adrenal gland and create an “Adrenal Dysfunction.” This may be a contributing factor to various health conditions ranging from obesity to allergies.

Adrenal hormones are full of anti-inflammatory and anti-oxidant properties that may help minimize allergic and life-threatening negative reactions, such as cancer and autoimmune disorders. These hormones also assist in the utilization of carbohydrates and fats, the conversion of protein and fats into energy, and gastrointestinal and cardiovascular function. Necessary to achieve optimal health, proper adrenal support is created by good nutrition, plenty of sleep, managing stress, exercising regularly, and replacement of hormones that are deficient.

Thyroid Hormones: T3 and T4

The Tyrosine hormone produced by the thyroid gland are primarily responsible for the regulation of metabolism.  A normal thyroid gland secretes both T3 hormone, (Triiodothyronine, the active form), and T4 hormone (Thyroxine, the inactive form) in all parts of the body. However, many patients with hypothyroidism are only treated with Levothyroxine (synthetic T4), causing some patients to remain symptomatic. T3 may also be needed for optimal thyroid replacement therapy and is only commercially available as synthetic Liothyronine sodium in an immediate release form. This can cause concentrations of T3 in the body that may be higher than normal and can cause serious side effects. There are many patients who find that the combination of T3 and T4 is their preferred method of treatment, especially when their response to T4 alone was not complete.

Thyroid Diseases

Hypothyroidism:  Low levels of thyroid hormones, known as hypothyroidism, can cause many different symptoms to appear in patients. They include things such as slowed metabolism, decreased heart rate, enlarged tongue, deep voice, weight gain, high cholesterol and triglycerides, hypoglycemia, memory impairment, depression, anxiety, constipation, headaches, low sex drive, fatigue, intolerance of hot and cold temperatures, fluid retention, irregular menstrual periods, aching muscles and joints, hypotension, and dry skin and/or hair. Even though the list of symptoms is extensive, over half of the people plagued by thyroid disease are not aware of their condition.

Subclinical Hypothyroidism

Subclinical Hypothyroidism, commonly known as Mild Thyroid Failure, presents patients with the symptoms of a thyroid deficiency, but with normal test results for thyroid function. There are many with thyroid dysfunction that have tried synthetic thyroid hormones and found that natural hormone replacement is the only form that works. Natural thyroid from a compounding pharmacy is an option for those who find these commercial products ineffective.

Chronic Fatigue Syndrome and Fibromyalgia

Most, if not all, of CFIDS/FM patients have an inadequate thyroid levels thanks to a combination of pituitary dysfunction, high reverse T3, and overall thyroid resistance. Levothyroxine is often found to be ineffective in a majority of these cases as well. In a compounded form, sustained-release T3 or a combination of T3 and T4 are normally the treatments with the highest success rates.

Treatment Options

Synthetic Thyroid Hormone

It is very common for patients to try Synthetic Thyroid Hormones, such as Levothyroxine and Liothyronine, and find that they do not respond to them well. These commercially available pills contain fillers and inactive drug ingredients that may not be tolerated by every patient.

Custom Compounding Medication:  As a Compounding Pharmacy, Hoye’s Pharmacy is able to blend certain forms and strengths of T4 and T3 pure powders in unique proportions as required by the patient’s prescription, which are also free of any problem-causing ingredients. These combinations may help patients that are unresponsive to the synthetic hormones.

Related Symptoms

Related Terms

  • Thyroid Stimulating Hormones (TSH)
  • T3
  • T4

Related Treatment Options